0:00to summarize our findings as into three main findings.
0:04Uh the first finding was that chip was uh indeed independently associated um with cardiovascular events in this cohort.
0:14And I should I I should give a little bit more context.
0:16This is a cohort of women who um provided blood samples at a at a median age of 80 years, so this was really an a sort of later life cohort of about 6,700 women who participated in the Women's Health Initiative Long Life Study.
0:31So, a study of sort of longevity, healthy aging and disease.
0:35Um, so these are these are these are women who enrolled in the original Women's Health Initiative in the mid 1990s and then participated in this follow-up study where they gave repeat blood sample repeated study assessments and then we're followed for outcomes.
0:46So, in this sort of much much older group, again, median age 80 at baseline, uh Chip did indeed associate independently with with cardiovascular events.
0:58I think the second key finding though and sort of related to something I mentioned earlier.
1:04Is that there appeared to be quite a bit of heterogeneity across these associations, both with respect to the key chip driver genes.
1:14So key subtypes of chip and also with respect to the specific cardiovascular outcomes.
1:22So, the three most common types of chip in the population.
1:28And this this gets to be an acronym soup very quickly.
1:32But the three big ones are DNMT3A, TET2, and ASXL1.
1:39And those genes together represent about 80% of chip in the population.
1:45And of those three, prior literature suggests that TET2 is sort of the worst actor when it comes to cardio adverse cardiovascular events.
1:55And so what we what we saw in our in our study here.
2:02in the Women's Health Initiative long life study, was that when we looked at chip as a broad.
2:08When we when we lumped all the chip jeans together, we actually didn't see any associations.
2:13So chip treated as a broad composite was negative.
2:16But it was when we looked at at each type individually is where we started to see to see the signals.
2:21And so TET2, again, the second most common type of chip in the population, TET2 chip, um was associated for example with both incident coronary heart disease and with heart failure with preserved ejection fraction or half.
